Erin's Guide to Kissing Girls follows Erin Hallard, a spunky, headstrong twelve-year-old girl in her attempt to woo the coolest girl in school, Sydni Hunter. Erin's plan is to ask Sydni to the annual spring fling with the help of her best friend and partner in crime, Liz Johnson. However, as Erin becomes wrapped up in her mission to get Sydni to go to the dance with her, it starts to put a strain on her friendship with Liz as Liz begins to feel less important in Erin's life.